Partners

X-Chem, Inc. has a mission to apply its powerful product engine to the discovery of small molecule leads against high-value therapeutic targets. X-Chem has established partnerships with AbbVie, Abilita Bio, Alexion, Astellas, AstraZeneca, Bayer, Department of Defense/Harvard, Gilead, Janssen, MD Anderson Cancer Center, Ono, Otsuka, Pfizer, Roche, Sanofi, Taiho Pharma, Vertex and several other leading pharmaceutical companies, biotechnology organizations and academic centers.

X-Chem’s DEX drug discovery engine is based on a collection of drug-like DNA-encoded libraries derived from iterative combinatorial chemistry processes, where the identity of each compound is recorded in a linked DNA barcode. The pooled libraries are used in low volume, affinity-based screening against biological targets, whereby ligands are ‘fished out’ and identified via DNA sequencing. Innovations in drug-like library design, screening methodologies, and cheminformatics underlie the industry-leading performance of the DEX platform. X-Chem has significantly increased the success rate against difficult and intractable targets that have failed in conventional screening, and has generated over 50 programs and over 150 independent chemical series licensed by X-Chem’s partners.

lntelliSyn is among the leading independent providers of drug discovery support in North America. Its experienced scientists have in-depth understanding of all aspects of medicinal chemistry and the expertise to accelerate drug discovery of clinically viable, maximally de-risked drug candidates.

Reaction Biology Corporation is an industry leader and innovator specializing in assay services and protein production for early-stage drug discovery.

Sai Life Sciences is a full-service contract development and manufacturing organization (CDMO) with a vision to propel the launch of 25 new medicines by 2025. Sai works with innovator pharma and biotech companies to accelerate the discovery, development and manufacture of complex small molecules for a healthier tomorrow.

Piramal is a global leader in integrated solutions and offers a unique platform of services across the drug lifecycle – from drug discovery and development to commercial manufacturing of drug substances and drug products.